顾汉研

研究随想 　加强防治新冠保护人类避免退化
（保护人类抑制器、刹车器ーACE2受体）
2022年4月10日  ·
新冠病毒肺炎大流行致新冠病毒进入人体细胞时所需要的ACE2受体损伤、而致人类智商体质等退化约几千年甚至到1万年左右（人类最后一次走出非洲并较快进化了约7到10万年)。从今以后有可能不能彻底清除仍温和流行、人仍缓慢少量退化。感谢清零防疫政策、中国大陆港台等国家和地区智商体质等退化损失可能全世界最小、病人比例最少！因打新冠疫苗、并执行隔离切断保护传染病3原则和细节等、无症状新冠病人比例已从约1/3增到约14/15、大多数为无症状病人、大好事！ACE2受体人体所有的系统器官组织中都有、作用广泛、是人类兴奋性的交感系统等等的抑制器、负作用蛋白酶、好比类似相当于汽车的刹车器、新冠病毒肺炎损伤甚至破坏了抑制器、刹车器而导致疾病、严重疾病甚至死亡（ACE2受体伴随人类进化了几亿年以上、重要而不能随意损坏的、要保护ACE2受体）。中国等等国家或地区的医学科学家、政治家、人民等努力抑制新冠病毒肺炎流行、保护人民、爱人类、防止退化。功德千秋。（22-4-7初稿、22-4-9第一次修改、草案，将进一步增、改）
(Google English translation: )
Research thoughts Strengthen the prevention and treatment of new crowns to protect humans from degeneration
(protect human suppressors, brakes - ACE2 receptors)
The new coronavirus pneumonia pandemic has caused damage to the ACE2 receptors required for the new coronavirus to enter human cells, resulting in the degradation of human IQ and physique for about several thousand years or even 10,000 years (the last time humans walked out of Africa and evolved quickly for about 70 years). to 100,000 years). From now on, it may not be completely eradicated, but it is still mildly prevalent, and people are still slowly and slightly degraded. Thanks to the clearing of the epidemic prevention policy, the degradation of IQ and physique in mainland China, Hong Kong and Taiwan and other countries and regions, the loss of IQ and physique may be the smallest in the world, and the proportion of patients is the smallest! Due to the new crown vaccine and the implementation of the three principles and details of isolation and protection of infectious diseases, the proportion of asymptomatic new crown patients has increased from about 1/3 to about 14/15, and most of them are asymptomatic patients, a good thing! ACE2 receptors are found in all system organs and tissues of the human body, have a wide range of functions, are inhibitors of the human excitatory sympathetic system, etc., negative-acting proteases, such as brakes that are equivalent to cars, and the new coronavirus pneumonia damages or even destroys inhibition ACE2 receptors have evolved with humans for more than hundreds of millions of years, and are important and cannot be damaged at will, and ACE2 receptors must be protected. Medical scientists, politicians, and people in China and other countries and regions are working hard to curb the spread of the new coronavirus, protect the people, love humanity, and prevent degradation. Merit forever. (The first draft of 22-4-7, the first revision and draft of 22-4-9, will be further added and revised)

https://www.facebook.com/hantao. ... QESPeQsoJu8v4ZzmTTl
https://www.facebook.com/hantao.gu.75

（小部分日美网页、中国大陆看不了，一小部分大陆网页、节目，日美看不了。）

顾汉研

Hantao Gu
推荐几篇新冠病毒肺炎ACE2受体（血管紧张素转换酶 2 ）关联等等的论文供参考：
（Several papers related to the ACE2 receptor (angiotensin-converting enzyme 2) associated with the new coronavirus pneumonia are recommended for reference: ）
1.nature articles article
Article Open Access
Published: 03 February 2022
ACE2 binding is an ancestral and evolvable trait of sarbecoviruses
（ACE2 结合是 sarbecoviruses 的祖先和可进化特征）
https://www.nature.com/articles/s41586-022-04464-z
2.nature articles article
Published: 20 June 2002
Angiotensin-converting enzyme 2 is an essential regulator of heart function
（血管紧张素转换酶 2 是心脏功能的重要调节剂）
https://www.nature.com/articles/nature00786
3.nature letters article
Published: 27 November 2003
Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus
（血管紧张素转换酶 2 是 SARS 冠状病毒的功能性受体）
https://www.nature.com/articles/nature02145
4.nature letters article
Published: 30 October 2013
Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor
（使用 ACE2 受体的蝙蝠 SARS 样冠状病毒的分离和表征）
https://www.nature.com/articles/nature12711
5.nature nature reviews microbiology review articles article
Review Article
Published: 10 December 2018
Origin and evolution of pathogenic coronaviruses
（致病性冠状病毒的起源和进化）
https://www.nature.com/articles/s41579-018-0118-9.
6.nature articles article
Article
Published: 22 April 2021
High-dimensional characterization of post-acute sequelae of COVID-19
(COVID-19 急性后遗症的高维表征)
https://www.nature.com/articles/ ... M-ffIVyQ_erYjvb4gR4
7.nature  articles  article
Article
Published: 30 March 2020
Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor
（与 ACE2 受体结合的 SARS-CoV-2 刺突受体结合域的结构）
https://www.nature.com/articles/s41586-020-2180-5
8.徐建青/张晓燕团队《PNAS》报道MYH9是SARS-COV-2感染的共受体——增强ACE2依赖性内吞作用以促进感染
https://ibs.fudan.edu.cn/76/26/c24338a423462/page.htm
https://www.pnas.org/doi/10.1073/pnas.2111011118
9.血管紧张素转化酶2与冠状病毒的“不解之缘”：感染与致病机制进展
http://rs.yiigle.com/CN112148202007/1207256.htm
10.Cell实锤：新冠病毒通过受体ACE2感染细胞！
https://m.beyotime.com/support/xinguanbingdu.htm?pagefrom=more7
11.新型冠状病毒受体ACE2在多种疾病中的作用
https://www.baidu.com/s?rsv_xinw ... 0%B5%C4%D7%F7%D3%C3
https://www.google.com/search?q= ... amp;sclient=gws-wiz
12.Computational Insights into the Conformational Accessibility and Binding Strength of SARS-CoV-2 Spike Protein to Human Angiotensin-Converting Enzyme 2
（对 SARS-CoV-2 刺突蛋白与人血管紧张素转换酶 2 的构象可及性和结合强度的计算见解）
https://pubs.acs.org/doi/10.1021/acs.jpclett.0c02958
13.守护ACE2——关闭SARS-CoV-2进入细胞的通道
https://www.cas.org/zh-hans/resource/blog/ace2-covid-19-target
14.Nature:SARS-CoV-2 is associated with changes in brain structure in UK Biobank
https://www.nature.com/articles/s41586-022-04569-5
轻症也会损伤大脑！《自然》报道：新冠感染或导致脑部退行性病变
https://www.linkresearcher.com/t ... dQohLGbDQliltTEmC-s
Nature：震惊！我国科学家领衔揭示两种与MERS-CoV亲缘关系最接近的蝙蝠冠状病毒使用蝙蝠ACE2受体进入宿主细胞
https://news.bioon.com/article/f433e52493ee.html
Close relatives of MERS-CoV in bats use ACE2 as their functional receptors
https://www.nature.com/articles/s41586-022-05513-3
Nature:广泛中和抗体克服 SARS-CoV-2 Omicron 抗原转变
https://www.nature.com/articles/s41586-021-04386-2
Nature重磅综述：如果不采取行动，长新冠或会造成终身残疾
Nature reviews microbiology: Long COVID: major findings, mechanisms and recommendations
https://news.bioon.com/article/3a19e56434bd.html
https://www.nature.com/articles/s41579-022-00846-2
Nature medicine  Review Article : Unexplained post-acute infection syndromes
自然  自然医学  评论文章: 无法解释的急性感染后综合征
https://www.nature.com/articles/s41591-022-01810-6
Nature：Virus-induced senescence is a driver and therapeutic target in COVID-19
https://www.nature.com/articles/s41586-021-03995-1
Nature Aging ：SARS-CoV-2 infection triggers paracrine senescence and leads to a sustained senescence-associated inflammatory response
https://www.nature.com/articles/s43587-022-00170-7
Science：Senolytics reduce coronavirus-related mortality in old mice
https://www.science.org/doi/10.1126/science.abe4832
Nature、Science等：新冠病毒会促进细胞衰老，从而导致长期后遗症的出现
新冠病毒感染细胞后，会诱导产生细胞衰老相关分泌表型（SASP），从而影响附近未感染细胞出现衰老样细胞周期停滞，而且这种影响即使在新冠病毒被清除后仍然持续存在。这提示了我们，新冠病毒感染导致的细胞衰老相关分泌表型（SASP）可能是导致“长期新冠”（Long COVID）的原因。本3篇论文是新冠病毒感染、促细胞衰老、长期后遗症等关联基础医学研究论文。
https://www.linkresearcher.com/t ... FUj58kg-qdV9QsfR8qE
Science：新研究揭示补体系统的持续激活会损害活动性长新冠患者体内的组织和血细胞
https://news.bioon.com/article/da5d81014811.html
Science：Persistent complement dysregulation with signs of thromboinflammation in active Long Covid
https://www.science.org/doi/10.1126/science.adg7942



[ 本帖最后由 顾汉研 于 2024-2-12 14:35 编辑 ]